![]() Keywords: medication adherence, tyrosine kinase inhibitors, chronic myeloid leukemia, systematic review, complex interventionsĬhronic myeloid leukemia (CML) is a myeloproliferative neoplasm with an annual incidence of 0.7 to 1.8 per 100,000 population. Further studies are required to clarify the cost-effectiveness of adherence-enhancing interventions. Only one study showed a significant association between intervention and clinical outcomes, with a 22.6% higher major molecular response rate and improvement in 6 out of 20 subscales of health-related quality-of-life.Ĭonclusion: Complex interventions delivered by healthcare professionals showed improvement in adherence to TKIs in CML patients. The improvement in the rate of TKI doses taken/received ranged from 1.5% to 7.1%. The relative proportion of participants who adhered to TKIs ranged from 1.22 to 2.42. Most (7 out of 9) studies demonstrated significantly better adherence to TKIs in the intervention group than the comparison group. All the included studies incorporated complex interventions, including intensive education or consultation with pharmacists, nurses or multidisciplinary team, in combination with one or more other strategies such as structured follow-up, written materials or video, psychotherapy, medication reminder or treatment diary, with the overall goal of monitoring and improving TKI adherence. Results: Nine studies were included in two randomised controlled trials, four cohort studies, and three before-and-after comparison studies. Medication adherence and clinical outcomes between intervention and control arms were compared. Relevant data on study characteristics were extracted. Studies that compared adherence enhancing interventions implemented by healthcare professionals with a comparison group were included. Methods: A systematic literature search was performed in 5 databases for articles published between 20. The current systematic review aimed to identify studies that evaluated adherence-enhancing interventions implemented by healthcare professionals and determine their effect on CML patients’ medication adherence and clinical outcomes. A recently published review by Heiney et al reported inconclusive findings on the effects of a broad range of adherence enhancing interventions. Purpose: Suboptimal adherence to tyrosine kinase inhibitors (TKIs) is a widely recognized issue compromising the disease control and survival of patients with chronic myeloid leukemia (CML). School of Pharmacy, Faculty of Health and Medical Sciences, Taylor’s University, Subang Jaya, Selangor, 47500, Malaysia The IBM SPSS Statistics demo is available to all software users as a free download with potential restrictions compared with the full version.Bee Kim Tan, 1 Ping Chong Bee, 2 Siew Siang Chua, 1 Li-Chia Chen 3ġSchool of Pharmacy, Faculty of Health and Medical Sciences, Taylor’s University, Subang Jaya, Selangor, 47500, Malaysia 2Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, 50603, Malaysia 3Centre for Pharmacoepidemiology and Drug Safety, Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, M13 9PT, UK It is part from other business category and is licensed as shareware for Windows 32-bit and 64-bit platform and can be used as a free trial until the trial period will end. ![]() With this program you can compute accurate statistical data and work with a more realistic figure. Alongside the information administration devices that assistance you process substantial informational indexes (information approval, copy recognizable proof, information correlation, variable arranging, record consolidating, part and rebuilding and so forth. The information supervisor incorporated into the bundle is like any spreadsheet application, empowering you to physically enter information or import a database from Cognos, Excel, content or tab-delimited records. This is a simple to-utilize set of prescient diagnostic instruments for business clients. With a drag & drop interface and multiple presets and templates included, IBM SPSS Statistics – formerly SPSS Statistics Desktop – will allow any user to create advanced reports. There is quite a bit more to the software which then enables the quick processing of the data. This computer software is marked as highly helpful for statistical calculations. Of course, you can do it yourself in Excel or other software, but this tool can automate the process. Aside from data analysis, the computer software embeds a wide array of services like data management provides exact case-control statistics and assorted tests alongside their predictions. If you have a lot of data, it has no value if you do not process it. ![]()
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